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NOVA scienceNOW: Stem Cells

NOVA scienceNOW: Stem Cells
What are they, and how do we find a balance between hope for cures and respect for life?

Thursday Nov 15, 2007 Monkey embryo clone another stem-cell first
Scientists have created the world's first cloned embryo from a monkey, the first successful cloning .

Thursday Jun 7, 2007 Embryonic stem cells made from mouse skin
New procedure bypasses need to destroy embryos

New stem cell rules allow 'fresh' embryos

Health agency authorizes project. Ethicists fear women will be coerced into donating days-old embryos

MARGARET MUNRO, CanWest News Service

Published: Tuesday, June 27, 2006

Canada's lead health research agency has for the first time authorized the use of days-old human embryos for a stem cell project.

The governing council of the Canadian Institutes of Health Research has given conditional approval for a controversial project to use "fresh" as well as frozen human embryos for stem cell research, officials said yesterday.

The $523,000 project, which has been under review for a year, will use surplus embryos donated by people who have undergone fertility treatment. The tiny embryos, composed of just a few cells, would be destroyed as the researchers try to harvest embryonic stem cells. The hope is that understanding the potent cells might one day lead to treatments for everything from Parkinson's disease to heart disease.

The project will be led by researchers in Toronto and will involve teams in Vancouver and Hamilton.

CIHR's approval is conditional on receipt of consent forms and other documents, said officials at CIHR, who posted details of the deliberations on the Internet.

The Canadian Stem Cell Network, a federally funded group, gave scientific and funding approval for the project last summer and has been waiting for CIHR's ethics approval ever since. There is "no reason" to think the conditions cannot be readily met, the network's executive director Drew Lyall said yesterday.

The project will be led by Andras Nagy at Toronto's Mount Sinai Hospital, Jamie Piret at the University of British Columbia and Mick Bhatia at McMaster University.

"It really is the blue-ribbon team of embryonic stem cell researchers in Canada," Lyall said. "It's an appropriate team that is leading these efforts."

The project is the first to come up for review since leading Canadian ethicists called for a moratorium and national debate on the use of fresh human embryos in stem cell research last year. The ethicists fear women might be coerced into donating their days-old embryos, and have argued better Canadian safeguards are needed to protect them.

After the call for a moratorium, CIHR's stem cell oversight committee asked the scientists for written assurance that coercion and money are not used to obtain embryos. The scientists were also asked to rewrite their consent forms to ensure donors are made aware of "all available options" for extra embryos and understand the fate of embryos used in stem cell research.

Human embryonic stem cells are being injected into everything from rodent brains to dog hearts as scientists try to develop "regenerative" treatments for failing bodies.

The embryonic cell lines produced from the project will be made available to other academics.

© The Gazette (Montreal) 2006





National Geographic Embryonic stem cells may someday help doctors treat ills from paralysis to diabetes. But science must contend with politics before that hope can be realized.

Find 107 Wednesday-Night pages on Stem-cell Wikipedia | search | clusty | Charlie Rose - Stem cell | U-tube |  TV AOL o> video

2008

Friday Jun 20, 2008 Stem cells offer new hope
Ever since Lucie Moisan developed pulmonary hypertension more than a decade ago, she's often been short...

Monday 09 June 2008 Fresh hurdle for stem cell hunt
It may be tougher than first thought to pick effective stem cell treatments, a Nobel Prize-winning geneticist says.

Friday 23 May 2008 Britain backs human-animal embryo research
After contentious free vote, Parliament defeats amendment to ban inter-species research

Monday 19 May 2008 UK Brown urges embryo bill support
Gordon Brown has called on MPs to back stem cell research using human-animal embryos in a Commons vote on Monday.
The prime minister, writing in the Observer, said such work was a "moral endeavour" and had the potential to save and improve "millions of lives".

Sunday 13 April 2008 Stem cell hope for osteoarthritis
Stem cells offer a potential way to repair cartilage damaged by osteoarthritis, say scientists.

Monday 18 February 2008

Stem cell hope for bone fractures
Bone cell
Some bone injuries are too severe to heal well
UK scientists hope to mend shattered bones and damaged cartilage using a patient's own stem cells.

They are developing a "bioactive scaffold" to protect the stem cells and encourage them to grow into bone or cartilage when placed in the body.

The Edinburgh University team hope the technique, which uses stem cells from blood and bone marrow, will be tested in patients within two years.

Tuesday 29 January 2008 Questioning the Allure of Putting Cells in the Bank
By ANDREW POLLACK
Some experts say consumers should think twice before spending money on storing stem cells, because it is not clear how useful they will be.

2007

Thursday 17 January 2008 MONTAGUE: CANADIAN GOES TO CHINA FOR STEM-CELL TRANSPLANT
A Canadian woman is travelling to to China to undergo a stem-cell transplant with the hopes it will improve her condition. Margo Oliver, of Montague Prince Edward Island, has multiple sclerosis, a disease that affects the central nervous system. She is going to China because the stem-cell transplant treatment is not allowed in North America. The treatment will be carried out at a clinic in Shenyang.

video Science writer Carl Zimmer, left, and biologist Lee Silver on whether a recent breakthrough will really end the stem-cell controversy

Wednesday Nov 21, 2007 Stem cells made from human skin
Bio-wizards have come up with "simple" recipes to reprogram skin cells and give them the power to become...
The teams have used genes to produce the potent cells from regular skin cells, avoiding the destruction of days-old human embryos, until now the source of the "pluripotent" cells, which can morph into any of the 200 different cell types in the body.
The new gene technique is expected to enable scientists to bypass many of the thorny ethical problems that have surrounded the field for close to a decade and hampered stem cell work in Canada, the U.S. and other countries.
"It's a stunning advance," says Dr. Michael Rudnicki, scientific director of the Canadian Stem Cell Network. "It has shocked a lot of people that it actually works." more

Sunday 11 November 2007 New Jersey’s Verdict on Stem Cells
The task of moving stem cell research to the next level cannot be left to the states - it needs to be underwritten by federal financing. [there is no wisdom that blocks STUDY even in Stem Cells]

Monday 24 September 2007 Of Animal Eggs and Human Embryos
There are distressingly few women willing to donate their eggs for experiments at the frontiers of stem cell research.

Thursday Jun 21, 2007 U.S. President George W. Bush has vetoed a bill that would have eased restraints on federally funded embryonic stem cell research. The move is to counter a push by members of the Democratic-led Congress, who have made the stem cell legislation a top priority and were quick to denounce the president's decision. Mr. Bush's spokesman says he does not believe it's appropriate to put an end to human life for research purposes. Embryonic stem cells come from days-old embryos and can produce any type of cell in the body. Scientists hope to harness the transformational qualities of stem cells to provide treatments for a variety of diseases, including Parkinson's disease, diabetes and spinal cord injuries.

Wednesday 20 June 2007 Genes that give stem cells their oomph identified
Canadian researchers uncover what makes stem cells so special – at a molecular level

Sunday 10 June 2007 House Votes to Expand Stem Cell Research
Democratic leaders conceded they were short of the votes needed to override a veto threatened by President Bush. more

Thursday 07 June 2007 Biologists Make Skin Cells Work Like Stem Cells
If a technique used in mice can be adapted to human cells, it would let scientists use a patient’s skin cells to generate new heart, liver or kidney cells.

Thursday 07 June 2007
Stem cells derived from other cells in regenerative medicine breakthrough
With a few strokes of genetic trickery, scientists have transformed mouse skin cells into embryonic stem cells and proved their potency by using the new cells to produce baby mice.

Wednesday 09 May 2007 nyt Mass. Proposes Stem Cell Research Grants
The $1.25 billion proposal is intended to help the state maintain its status as a pre-eminent place for research.

- Feb 19, 2007 Charlie Rose A wide-ranging hour-long conversation with author Michael Crichton. His latest book is "Next". Genes

Friday 23 February 2007 Satellite radio merger not so friendly up north Canadian units battling for market share

21/02/07 RIM chief predicts big changes in Internet music delivery
Content providers' attempts to protect online content holding up development of wireless industry, Balsillie says

Monday Jan 8, 2007 cbc SCIENTISTS ISOLATE NEW STEM CELL SOURCE
U.S. scientists say they have isolated a new type of stem cell, a discovery they believe could someday provide a ready means of repairing or replacing diseased organs in patients.

Monday Jan 8, 2007 Stem cells in amniotic fluid show promise
By Karen Kaplan /LA Times Staff Writer
Researchers have found that some stem cells in human amniotic fluid appear to have many of the key therapeutic benefits of embryonic stem cells while avoiding their knottiest ethical, medical and logistical drawbacks, according to a study published...

2006

Thursday 30 November 2006 globe Lawmakers begin debating legislation this week that would lift ban on cloning human embryos

Monday 20 November 2006 globe Stem cells core of more cancers
New discoveries that pinpoint bad seeds leading to a major redirection of research
A spate of new discoveries about the basic biology of cancer is pushing researchers toward an astonishing conclusion: For decades, efforts to cure the disease may have targeted the wrong cells.

Monday 13 November 2006 bbc Stem cells: Hope or hype?
Getting stem cells into the clinic is seen as the Holy Grail of medicine.
Injections of these cells, which have the special ability to transform into any other cells, have been paraded as the panacea for diseases, from Parkinson's to diabetes.

Friday 10 November 2006 ap Senate votes to lift Australian ban on stem cell cloning
Canberra, Australia — Australia's Senate narrowly voted Tuesday to lift the country's ban on cloning human embryos for stem cell research.
The bill, which was approved 34-32, would relax rules on stem cell research and allow therapeutic cloning of embryos for medical research. The House of Representatives still needs to pass the bill before it becomes law, but lawmakers had expected the Senate to pose the biggest hurdle.

Tuesday 31 October 2006 nyt Ethics & The Nazi Past video
In part two of an interview, Nobel laureate Christiane Nüsslein-Volhard describes stem cell research and the ethical debate in the U.S. and Germany. (Producer: Craig Duff).
Solving a Mystery of Life, Then Tackling a Real-Life Problem

Friday 27 October 2006 globe A sobering setback in stem-cell research Researchers essentially cure rats of a Parkinson's-like disease but brain tumour grow in every animal treated

Monday 04 September 2006 STAVELY: STEM CELLS USED TO TREAT HORSES
For what appears to be the first time, Canadian scientists have performed a stem cell treatment on horses. Veterinarians at the Alberta Equine Hospital in Stavely, Alberta, implanted stem cells into five horses that have problems with their joints. Unlike human stem cells that are taken from embroys, the stem cells used in the operation were taken from the horses' tails. There were some legal complications, however. Canadian government officials long prevented the stem cell material from crossing back into the country after it was sent for processing at a laboratory in the United States. Similar operations on horses in the United States have led to success in treating joint ailments.

Thursday 24 August 2006 globe New stem cell technique may help solve political, ethical debate
The breakthrough technique could yield a source of human embryonic stem cells for medical research — and, possibly, future treatments — free of the moral and ethical concerns that have mired the field.

nyt In New Method for Stem Cells, Viable Embryoshttp://www.theglobeandmail.com/servlet/story/RTGAM.20060823.wstemcell0823/BNStory/Science/?cid=al_gam_nletter_newsUpThe new technique would seem to remove the principal objection to stem cell research, the destruction of the human embryo.

August 1, 2006 nyt A Pox on Stem Cell Research
Medical progress has stirred religious and moral objections throughout history — objections that were overcome as the benefits of medical advances became overwhelmingly obvious.

Sunday 06 August 2006 nyt Video Stem Cell, Ethics and the Nazi PastIn part two of an interview, Nobel laureate Christiane Nüsslein-Volhard describes stem cell research and the ethical debate in the U.S. and Germany. (Producer: Craig Duff). Solving a Mystery of Life, Then Tackling a Real-Life Problem | Stem Cells May Be Key to Cancer

Stem-cell therapy, once the stuff of science fiction, may soon be a reality for patients suffering from conditions as diverse as cancer, heart disease, broken bones and paralysis. The latest figures show that stem cells are involved in around 600 clinical trials worldwide, and with President Bush banning federal funding for research using one type of stem cell - embryonic - and Tony Blair championing the science in California this week, the UK looks set to attract much more research.


Stem Cells: The Hope And The Hype
The debate is so politically loaded that it's tough to tell who's being straight about the real areas of progress and how breakthroughs can be achieved. TIME sorts it out
When there's nothing else to prescribe, hope works like a drug. A quadriplegic patient tells herself it's not a matter of if they find a cure but when. Who's to say whether salvation is still 10 or 15 years away? After all, researchers have been injecting stem cells into paralyzed rats and watching their spinal cords mend. "Stem cells have already cured paralysis in animals," declared Christopher Reeve in a commercial he filmed a week before he died.

Mon 24/07/2006 BELGIUM
The 25 member states in the European Union will continue financing human stem cell research despite opposition from eight countries led by Germany.
The funding will only be available in E-U countries that allow embryonic stem cell research under strict conditions.

Monday Apr 24, 2006 ts
A federal committee has put the brakes on a controversial project that aims to create stem cells from days-old human embryos.

Sunday Mar 26, 2006 nyt video Stem Cells and Cancer

Tuesday Feb 21, 2006 nyt Stem Cells May Be Key to Cancer By NICHOLAS WADE
A far more pressing reason to study stem cells is the fact that they are the source of at least some, and perhaps all, cancers.

Tuesday Jan 24, 2006 nyt At Harvard's Stem Cell Center, the Barriers Run Deep and Wide
By CLAUDIA DREIFUS
Even before President Bush barred federal financing for most human embryonic stem cell research, the work of Douglas Melton was mired in controversy. 40 W-Ns that talked about Stemcells

2005

Friday Dec 30, 2005 rci More discredit is falling on South Korean scientists who claimed to make breakthroughs in stem cell research. An inquiry by the National University in Seoul has found no data to support claims by the university's scientists that they created stem cells to match specific people. The inquiry determined that the stem cells in question came from human egg cells obtained at a local hospital. Last week, the same inquiry accused scientists of fabricating their research results. The accusation caused a major scandal and led to the resignation of South Korea's most celebrated scientist, Hwang Woo-suk.

Monday Dec 19, 2005 ec The work of Hwang Woo-suk, a stem-cell pioneer and a hero in his native South Korea, has been called into doubt
KOREANS are sometimes accused of suffering from a “bali, bali” or “quick, quick” complex; of sacrificing quality and thoroughness to speed and a driving desire to achieve. In Hwang Woo-suk, heralded as the world’s leading stem-cell researcher, this trait has resulted in, at best, sloppy science; at worst audacious fraud.

Saturday Dec 10, 2005 nyt California's Stem Cell Program Is Hobbled but Staying the Course
By ANDREW POLLACK
More than a year after Californians approved a program to harness human embryonic stem cells to treat diseases, not a single dollar has yet been spent on research.

17 Oct 2005 Embryonic stem cells without destroying embryos, jumping the moral hurdle

Tuesday Oct 18, 2005 nyt Stem Cell Side Shows
It would be foolish to abandon proven techniques to derive stem cells just to meet the ethical objections of a minority.

Monday Oct 17, 2005 nyt Stem Cell Test Tried on Mice Saves Embryo
By NICHOLAS WADE
A new technique to derive embryonic stem cells in mice that does not destroy an embryo could shift the political debate about human stem cell research.

October 17, 2005 nyt Stem Cell Test Tried on Mice Saves Embryo
Scientists have devised two new techniques to derive embryonic stem cells in mice, one of which avoids the destruction of the embryo, a development that could have the potential to shift the grounds of the longstanding political debate about human stem cell research.

October 16, 2005 nyt Scientists Devise Stem Cell Methods to Ease Concerns
By NICHOLAS WADE
In a development that may shift the debate over embryonic stem cells, researchers have devised two new techniques designed to alleviate ethical concerns.

Sunday Oct 9, 2005 ew US Sets Up National Stem-Cell Bank
The University of Wisconsin, where human embryonic stem cells were first isolated, will host the first federally funded bank of the valuable cells, the U.S. government has announced.

Friday Aug 26, 2005 ew US Sets Up National Stem-Cell Bank
University of Wisconsin, where human embryonic stem cells were first isolated, will host the first federally funded bank of the valuable cells, the U.S. government has announced.

Friday Sep 23, 2005 ec Stem cells and business The commercial potential of stem cells

Friday Aug 26, 2005 ts Article on fetal pain sparks outcry
CHICAGO The editor of a medical journal that published an article this week saying fetuses likely don't feel pain until late in pregnancy said yesterday she has received dozens of angry emails from abortion opponents.

Tuesday Aug 23, 2005 ts Fusion produces embryo-like stem cell
BOSTON—Harvard scientists have created cells similar to human embryonic stem cells without destroying embryos, a major step toward someday possibly defusing the central objection to stem cell research.

Thursday Aug 18, 2005 ew Opinion: Timing Favors Stem Cell Supporters
As one leading U.S. senator throws support behind research, another senator is poised to link the issue with the Supreme Court nomination debate.

Monday Aug 1, 2005 nyt Senate's Leader Veers From Bush Over Stem Cells
Senator Bill Frist has decided to support a bill to expand federal financing for embryonic stem cell research.

Saturday Jul 23, 2005 nyt Stem Cell Bill, Once Seen as a Sure Thing, Is Now Mired in Uncertainty
By SHERYL GAY STOLBERG
The bill would permit federal financing for research on stem cell lines derived from embryos that are in frozen storage at fertility clinics.

Tuesday Jun 21, 2005 StemCells (STEM : NASDAQ : US$4.21)
Net Change: 0.10, % Change: 2.43%, Volume: 3,103,300 Egg-static! The BBC was reporting yesterday that scientists have taken the first step towards creating human eggs and sperm in the laboratory using stem cells. The breakthrough raises the possibility of one day growing sperm and eggs artificially for in vitro fertilization treatment, therapeutic cloning and medical research. In case you're new to all of this, stem cells are called "master" cells that under the right conditions can develop into different kinds of tissue. In fact, those extracted from early stage embryos can potentially become any of the 165 different kinds of cell in the body. Researchers at the University of Sheffield in the U.K. have already shown that embryonic stem cells from mice can be coaxed into becoming eggs and sperm. But now a first step towards the same goal has been achieved with humans. Some experts warned, however, that the discovery raised serious ethical questions, saying that it could mean that a single man could provide both the sperm and egg for fertility treatment, making him genetically both parents of his child. Hey, remember that show, "My Two Dads"?

Thursday Jun 16, 2005 cc StemCells (STEM : NASDAQ : US$4.19)
Net Change: 0.32, % Change: 8.27%, Volume: 3,106,200
A limitless supply of brain cells...Whoa. The stem cell sector was showing strength yesterday on reports that U.S. scientists have duplicated the generation of new adult brain cells in the lab in a controlled way. The study, by the McKnight Brain Institute, is published in Proceedings of the National Academy of Sciences. It is hoped the technique, tested so far on animal cells, will eventually allow scientists to produce a limitless supply of a person's own brain cells. It is not the first time that immature stem cells have been manipulated in the laboratory to become brain cells. But the researchers say nobody else has replicated the process of cell maturation that goes on in the brain in such complete and close step- by-step detail before. For those who don't know, a little more than a decade ago, scientists came to realize that the brain continues to produce small amounts of new cells even in adulthood. The researchers at McKnight Brain believe they could potentially be used to treat disorders like Parkinson's disease and epilepsy. Godspeed.

Friday Jun 10, 2005 ts
Stem cell advance Researchers at Mount Sinai Hospital have developed Canada`s first two human embryonic stem cell lines, providing new tools to find treatments and cures for many chronic and fatal diseases.

WASHINGTON | May 26, 2005 nyt
Sponsor of Stem Cell Bill Says Senate Could Override a Veto
By SHERYL GAY STOLBERG
Senator Arlen Specter said he had enough votes in the Senate to override a presidential veto of a bill to expand federal financing for human embryonic stem cell research.

Thursday May 26, 2005 Canaccord Capital: StemCells (STEM : NASDAQ : US$3.97)
Net Change: 0.10, % Change: 2.59%, Volume: 3,950,800
A non-offensive, and unbiased tagline followed by a neutral comment. Shares rallied yesterday for Stemcells after U.S. senators called for a vote on legislation to expand federal funding of embryonic stem-cell research after the House of Representatives approved such a measure on Tuesday. Proponents of stem-cell research are trying to build momentum in the Senate after 50 Republicans defied their leaders in the House on Tuesday's vote. However, a policy President George W. Bush announced in August 2001 limits federal funding to embryonic stem cells in existence at the time because creating new ones requires the destruction of human embryos. The House-passed legislation would ease Bush's limits. Bush last week said he would veto the measure. Stemcells is involved in the research and development of therapies that would use stem and progenitor cells to treat and possibly cure human diseases and injuries. These therapies are developed to treat and cure neurodegenerative diseases, demyelinating disorders, spinal cord injuries, stroke, hepatitis, chronic liver failure, and diabetes.

Wednesday May 25, 2005 ts U.S. House okays cash for embryos in research
WASHINGTON—In a dramatic clash over U.S. President George W. Bush`s much-vaunted "culture of life," the Republican-led U.S. Congress ignored his veto threat and voted yesterday to extend federal funding for embryonic stem cell research.



the Stem Cell Debate






The dogs bark, but the caravan moves on
Sunday May 22, 2005 The Economist

Sunday May 22, 2005 bbcBush 'would veto' stem cell bill
US President George W Bush has said he will veto any legislation that would ease restrictions on embryonic stem cell research in the United States.
He was speaking a day after South Korean scientists announced they had made stem cells tailored to the individual for the first time. [God: You have his ear pleaes help him save lives]

Sunday May 22, 2005 bbcStem cells tailored to patients
South Korean scientists say they have made stem cells tailored to match the individual for the first time. Each of the 11 new stem cell lines that they made were created by taking genetic material from the patient and putting it into a donated egg.

Sunday May 22, 2005 ecThe dogs bark, but the caravan moves on
This week saw more progress in the study of human stem cells. It brings closer the day when replacement tissues—and perhaps even entire organs—can be grown in laboratories for patients who need them. But such research remains highly controversial




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